Acryloyl chloride → HCID 18520795, compound

HRID 1607379Notes

Reaction equation

HRID 1607379 reaction equation
[CH3:1][O:2][CH:3]([O:8][CH3:9])[CH:4]([NH2:7])[CH2:5][CH3:6].[C:10](Cl)(=[O:13])[CH:11]=[CH2:12]>C(Cl)Cl>[CH3:1][O:2][CH:3]([O:8][CH3:9])[CH:4]([NH:7][C:10](=[O:13])[CH:11]=[CH2:12])[CH2:5][CH3:6]

Participants

4

Reactant 2

HCID 13140Acryloyl chlorideHCID 22145177HCID 22145177, compound

Product 1

HCID 18520795HCID 18520795, compoundYield 68.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using the standard procedure for ABDA-Et, 16.5 g (0.124 mol) of the above aminobutyraldehyde dimethyl acetal was reacted with 11.2 g (0.124 mol) of acryloyl chloride in 40 mL of CH2Cl2 /30 g of 14N NaOH. The product mixture was adjusted to pH 10.0 and worked up as usual to yield 16 g of oil showing predominantly a single component by gc at 7.00 min.

Sources & evidence

ORD record
ord-2453f981e60f4e12adc7ec23ad676d20
Source dataset
uspto-grants-1989_09
Patent number
US04864055

Reaction notes

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