反应详情

To a solution of 2.76 g of 2-(1-naphthylmethyl)-2-(4-phenylbutyl)malonic acid diethyl ester in 20 ml of dimethyl sulfoxide and 0.5 ml of water was added 1.27 g of lithium chloride, and then the mixture was heated for 8 hours at from 180° to 190° C. After cooling, to the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 2.06 g of 2-(1-naphthylmethyl)-6-phenylhexanoic acid ethyl ester as a light brown oil.

1. temperaturethe mixture was heated for 8 hours at from 180° to 190° C
2. temperatureAfter cooling, to the reaction mixture
3. extractionthe mixture was extracted with ethyl acetate
4. washThe organic layer was washed with a saturated sodium chloride aqueous solution
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated under reduced pressure