反应详情

A solution of 500 mg of 2-(1-naphthylmethylene)-3-(phenethylcarbamoyl)propionic acid in 50 ml of acetic acid was hydrogenated over 250 mg of a 10% palladium/charcoal under a hydrogen atmosphere at room temperature. After filtration of the catalyst, the filtrate was concentrated under reduced pressure, and hexane was added to the residue. The precipitates were collected to obtain 500 mg of (±)-2-(1-naphthylmethyl)-3-(phenetylcarbamoyl)propionic acid as colorless crystals.

1. filtrationAfter filtration of the catalyst
2. concentrationthe filtrate was concentrated under reduced pressure, and hexane
3. additionwas added to the residue
4. customThe precipitates were collected