反应详情

To a solution of 1.5 g of the malonic acid diethyl ester obtained in 10 ml of dimethyl sulfoxide and 0.3 ml of water was added 0.92 g of lithium chloride, and the mixture was heated for 4.5 hours at from 180° to 190° C. After cooling, water was added to the reaction mixture, and the mixture was extracted with diethyl ether. The ethereal layer was washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 0.85 g of 2-(1-naphthylmethyl)-5-phenyl-4-pentenoic acid ethyl ester as a yellow oil.

1. temperaturethe mixture was heated for 4.5 hours at from 180° to 190° C
2. temperatureAfter cooling
3. extractionthe mixture was extracted with diethyl ether
4. washThe ethereal layer was washed with a saturated sodium chloride aqueous solution
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated under reduced pressure