Hydrochloric Acid → HCID 70385785, compound

Participants

Reaction Steps

A solution of 6.22 g of 2-cyano-3-(1-naphthyl)propionic acid ethyl ester and 50 ml of a 2N-hydrochloric acid in 300 ml of ethanol was hydrogenated over 600 mg of platinum oxide under atmospheric pressure. After filtration of the catalyst, the filtrate was concentrated under reduced pressure, and water was added to the residue. The mixture was washed with diethyl ether to remove neutral materials. The aqueous layer was neutralized by adding sodium bicarbonate, and then extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution and dried over anhydrous magnesium sulfate. An absolute ethanol solution containing hydrogen chloride was added to the organic layer. The organic layer was concentrated under reduced pressure, and hexane was added to the residue, and the resulting precipitates were collected by filtration to obtain 3.20 g of 3-amino-2-(1-naphthylmethyl)propionic acid ethyl ester hydrochloride as colorless crystals.

Provenance & Evidence