Hydrochloric Acid → HCID 178445915, compound

Participants

Reaction Steps

To a solution of 1.82 g of N-[2-(1-naphthylmethyl)-6-phenylhexanoyl]-L-histidyl-L-leucinal semicarbazone in 80 ml of methanol were added 29 ml of 1N-hydrochloric acid and 7.6 ml of a 37 wt% formaldehyde solution while ice-cooling under an argon atmosphere. The mixture was stirred for 1.5 hours at room temperature, and then a 5% aqueous sodium bicarbonate solution was added to the reaction mixture. The mixture was extracted with ethyl acetate, and the organic layer was washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 1.55 g of N-[2-(1-naphthylmethyl)-6-phenylhexanoyl]-L-histidyl-L-leucinal as a white powder.

Provenance & Evidence