4-Methylmorpholine → HCID 178501400, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 330 mg of 2-benzylidene-3-(1-naphthylmethylcarbamoyl)propionic acid, 260 mg of N,N'-disuccinimidylcarbonate and 1 ml of pyridine in 20 ml of dry acetonitrile was stirred for 3 hour at room temperature. The solution was added to a solution of 300 mg of L-histidine methyl ester dihydrochloride and 150 mg of N-methylmorpholine in 20 ml of dry N,N-dimethylformamide, and the mixture was stirred for 16 hours at 40° C. The reaction mixture was concentrated under reduced pressure, and a 5% aqueous sodium bicarbonate solution was added to the residue. The precipitates were collected by filtration to obtain 350 mg of N-[2-benzylidene-3-(1-naphthylmethylcarbamoyl)propionyl]-L-histidine methyl ester as a white powder.

Provenance & Evidence