1-chloro-2,4-dimethoxy-3,5-dinitrobenzene → HCID 18779321, compound

Participants

Reaction Steps

2,4-Dimethoxy-3,5-dinitrochlorobenzene is reduced with iron in the presence of acetic acid, at a temperature of between 50° and 100° C. 2,4-Dimethoxy-3,5-diaminochlorobenzene is thereby obtained, and this is then subjected to a dehalogenation reaction. This reaction is performed in water, in a lower alcohol or in an aqueous-alcoholic mixture, in the presence of palladium on charcoal, ammonium acetate and triethylamine formate, at a temperature between 50° C. and the refluxing temperature of the solvent.

Provenance & Evidence