Sodium Hydroxide → HCID 19751970, compound

HRID 1607483Notes

Reaction equation

HRID 1607483 reaction equation
S([O-])(O[CH3:5])(=O)=O.[S:7]([NH:17][C:18]1[C:19]([O:30][CH3:31])=[C:20]([N+:27]([O-:29])=[O:28])[C:21]([O:25][CH3:26])=[C:22]([Cl:24])[CH:23]=1)([C:10]1[CH:16]=[CH:15][C:13]([CH3:14])=[CH:12][CH:11]=1)(=[O:9])=[O:8].[OH-].[Na+]>>[S:7]([N:17]([C:18]1[C:19]([O:30][CH3:31])=[C:20]([N+:27]([O-:29])=[O:28])[C:21]([O:25][CH3:26])=[C:22]([Cl:24])[CH:23]=1)[CH3:5])([C:10]1[CH:11]=[CH:12][C:13]([CH3:14])=[CH:15][CH:16]=1)(=[O:8])=[O:9]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 4694097Methyl sulfate(1-)HCID 19751982HCID 19751982, compound

Product 1

HCID 19751970HCID 19751970, compound

Procedure

0.022 mole (2.1 ml) of methyl sulphate was added at 30°-35° C. to a solution of 0.02 mole (7.7 g) of 5-(N-tosylamino)-2,4-dimethoxy-3-nitrochlorobenzene prepared in the previous step in 25 ml of a normal solution of sodium hydroxide. Stirring was continued for 15 minutes after completion of the addition. The expected product precipitated upon dilution of the reaction mixture with iced water. After thorough draining and washing with water, the product obtained was recrystallized from alcohol.

Workup

  1. additionafter completion of the addition
  2. customThe expected product precipitated upon dilution of the reaction mixture with iced water
  3. washAfter thorough draining and washing with water
  4. customthe product obtained
  5. customwas recrystallized from alcohol

Sources & evidence

ORD record
ord-c66ffebaca9c433a85d648175d4ca765
Source dataset
uspto-grants-1989_09
Patent number
US04865618

Reaction notes

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