1,3-Propanediol → HCID 19751957, compound

Participants

Reaction Conditions

Reaction Steps

1 mole (271.5 g) of 3,5-dinitro-1,2,4-trichlorobenzene was added to 700 ml of 1,3-propanediol at 85° C. 2 moles of powdered potassium hydroxide in 280 ml of 1,3-propanediol were added over 30 minutes. The reaction mixture was heated for 1 hour at 85° C. upon completion of the addition. After cooling, the expected product was filtered off, washed with water, and then dissolved in 1.5 liters of ethyl acetate which, after washing with water, was dried over sodium sulphate. After concentration to dryness, a precipitate was obtained which, after having been recrystallized from isopropyl ether, melted at 90° C.

Provenance & Evidence