Ammonium Hydroxide → HCID 13714630, compound

Participants

Reaction Steps

A mixture of 4-chloroandrost-4-ene-3,17-dione (1.93 g, 6 mmole), dioxane (60 ml) and 30% NH4OH aqueous solution (120 ml) is stirred at room temperature during 24 hours. The organic solvent and excess of ammonia are evaporated in vacuo and the resulting aqueous residue is acidified to pH 1 by carefully adding conc. HCl. The aqueous solution is washed twice with ethyl acetate and brought to pH 11 by carefully adding conc. NaOH. The resulting precipitate is filtered off, washed with water and dried under vacuum at 40° C. There are obtained 559 mg (1.86 mmole, 31% yield) of the title compound as a white solid.

Provenance & Evidence