反应详情

A mixture of 19.7 g of the thus obtained 2-amino-5-heptylthio-1,3,4-thiadiazole, 40.9 g of bis (2,4,6-trichlorophenyl) 2-methyl-malonate and 55 ml of chlorobenzene was stirred at 140°~144° C. for 45 minutes. After cooling, n-hexane was added thereto, the precipitate was collected by filtration. Further n-hexane was added to the filtrate, and the precipitate was collected. The collected precipitates were combined. The combinedprecipitate was washed with n-hexane and thus 21.2 g of 2-heptylthio-7-hydroxy-6-methyl-5H-1,3,4-thiadiazolo-[3,2-a]pyrimidin-5-one was obtained.

1. temperatureAfter cooling
2. filtrationthe precipitate was collected by filtration
3. additionFurther n-hexane was added to the filtrate
4. customthe precipitate was collected
5. customThe collected precipitates
6. washThe combinedprecipitate was washed with n-hexane