Methanol → HCID 53826391, compound

Participants

Reaction Steps

Following the procedure of Example 1 to methyl-2-[[7-(3-chlorophenylsulphamoyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]methyl]benzoate, substituting methyl-5-(chloromethyl)-2-furoate (1.75 g, 10 mmol) for methyl-2-(bromomethyl)benzoate and using corresponding proportions of other reagents, gave methyl-5-[[7-(3-chlorophenylsulphamoyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]methyl]-2-furoate (2.86 g, 62%), m.pt. 167°-168° C. (from methanol).

Provenance & Evidence