Formic Acid → HCID 10442279, compound

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Reaction Steps

A solution of 8 (0.70 g, 0.0028 mol) in formic acid (20 ml) and 35% formaldehyde (7 ml) was refluxed overnight. The solution was evaporated in vacuo, and the residue was taken up in ether (20 ml) and 28% sodium hydroxide (20 ml). The phases were separated, and the aqueous phase was extracted three times with dichloromethane (20 ml). The combined organic phases were washed four times with saturated sodium chdloride solution (20 ml). The organic phase was dried over magnesium sulphate and evaporated in vacuo yielding 0.60 g or crude 10. Crystallization from ether-light petroleum gave 0.37 g (0.0021 mol, 74%) of title compound, M.P. 86°-87° C. Anal. (C8H13N5) C, H, N.

Provenance & Evidence