反应详情

6-(Benzyloxy)indole dissolved in a mixture of dioxane and pyridine was stirred at 60 C. under nitrogen while chloroacetyl chloride in dioxane was added dropwise during 1 hr. The reaction mixture was then stirred for another 0.5 hr. and poured into diethyl ether-water. The precipitate was collected by filtration and washed thoroughly with cold diethyl ether to yield 47% of 11 as an orange solid.

1. stirringThe reaction mixture was then stirred for another 0.5 hr
2. filtrationThe precipitate was collected by filtration
3. washwashed thoroughly with cold diethyl ether