HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 3-Hydroxyacetyl-6-(benzyloxy)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3-Chloroacetyl-6-(benzyloxy)indole | HCID 10902637 | — |
| Reactant | Formamide--water (1/1) | HCID 13001166 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Hydroxyacetyl-6-(benzyloxy)indole | HCID 14168301 | 82% |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
A solution of 11 in dioxane was added to formamide-water (10:1). The mixture was stirred at 110° C. for 10 hrs., then worked up and purified as described above to yield 82% of 13 as colorless prisms with mp 194°-195° C. (EtOAc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04866084 |
| Source dataset | uspto-grants-1989_09 |
| ORD ID | ord-e6c7b58cdebc4ee5bf79639f88691b22 |
| Source note | uspto-grants-1989_09 |