HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1607610Generated: November 2, 2026
3-Chloroacetyl-5-(benzyloxy)indole → 3-Hydroxyacetyl-5-(benzyloxy)indole
https://huagongshe.com/reaction/1607610
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Chloroacetyl-5-(benzyloxy)indole | HCID 10891912 | — |
| Reactant | Formamide--water (1/1) | HCID 13001166 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Hydroxyacetyl-5-(benzyloxy)indole | HCID 14168303 | 55% |
Reaction Steps
A solution of 19 in dioxane was added to formamide-water (10:1) and the mixture was stirred at 110° C. for 6.5 hrs., then was worked up as for 12 above. Purification by column chromatography gave 20 (55%) whose structure was established by spectral data. Calcd for C17H15NO3 : 281.1052 Found: 281.1052 (HREIMS).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04866084 |
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| Source dataset | uspto-grants-1989_09 |
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| ORD ID | ord-321b918c849a4c6e8261e37ca3c00cd7 |
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| Source note | uspto-grants-1989_09 |
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