Water → HCID 19818669, compound

HRID 1607612Notes

Reaction equation

HRID 1607612 reaction equation
[Br:1]Br.[C:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][N:8]=1)(=[O:6])[CH2:4][CH3:5].O>C(Cl)(Cl)Cl>[Br:1][CH:4]([CH3:5])[C:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:14])[F:15])=[CH:9][N:8]=1)=[O:6]

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 19818686HCID 19818686, compound

Product 1

HCID 19818669HCID 19818669, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

Bromine (0.52 ml.) in chloroform (50 ml.) was added to solution of 2-propionyl 5-trifluoromethylpyridine (2.03 g.) in chloroform (20 ml.) over 1 hour under photoflood illumination. After addition was complete the reaction was stirred for 16 hours at room temperature. The reaction was then poured into water, and the organic phase was separated, washed with water, dried over magnesium sulphate and concentrated to dryness to give 2-(2-bromopropionyl)-5-trifluoromethylpyridine as an oil which was used without further purification.

Workup

  1. additionAfter addition
  2. customthe organic phase was separated
  3. washwashed with water
  4. dry with materialdried over magnesium sulphate
  5. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-d20a01df67894e4dac6c673f7da09103
Source dataset
uspto-grants-1989_09
Patent number
US04866086

Reaction notes

Loading…