Methyl iodide → HCID 14453663, compound

Participants

Reaction Steps

In 80 ml of methyl-ethyl-ketone 4.2 g (20 millimoles) of 6,7-dihydroxy-2,3-dimethyl-4-chromanone are dissolved. To the solution 6.4 g (60 millimoles) of sodium carbonate and 8.5 g (3.8 ml, 60 millimoles) of methyl iodide are added and the reaction mixture is refluxed for 4 hours. After addition of a further 2.8 g (1.2 ml, 20 millimoles) of methyl iodide the reaction mixture is refluxed for further 3 hours. The reaction mixture is worked up according to Example 1. Thus 4.3 g of the desired compound are obtained, yield 91.0%. Mp.: 171°-172° C.

Provenance & Evidence