HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → Ethoxyprecocene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 4H-1-Benzopyran-4-one, 2,3-dihydro-6,7-dimethoxy-2,2-dimethyl- | HCID 103373 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Product | Ethoxyprecocene | HCID 127846 | 88% |
Reaction Steps
In 80 ml of anhydrous tetrahydrofurane 5.0 g (20 millimoles) of 6-methoxy-7-methoxy-2,2-dimethyl-4-chromanone are dissolved whereupon 1.5 g of lithium aluminum hydride are added in small portions under stirring and the reaction mixture is heated to boiling for an hour. The reaction mixture is worked up according to Example 31. The product is purified by column chromatography. Thus 4.1 g of the desired compound are obtained in the form of a colorless oil, yield 88%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04866089 |
| Source dataset | uspto-grants-1989_09 |
| ORD ID | ord-9a53fcbe4a39471b82e18eec502761f5 |
| Source note | uspto-grants-1989_09 |