Ammonium Chloride → HCID 10061288, compound

Participants

Reaction Steps

A mixture of 3'-(2,4-difluorophenoxy)-4'-nitroacetophenone (2.5 g), iron powder (2.5 g) and ammonium chloride (0.25 g) in ethanol (40 ml) and water (20 ml) was refluxed with stirring for 30 minutes. The insoluble materials were filtered and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, washed with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate, and concentrated to give a powder of 4'-amino-3'-(2,4-difluorophenoxy)acetophenone (2.2 g).

Provenance & Evidence