Ethanol → HCID 10426327, compound

HRID 1607666Notes

Reaction equation

HRID 1607666 reaction equation
[F:1][C:2]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:3]=1[O:4][C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[N+:14]([O-:16])=[O:15])[C:8]([OH:10])=[O:9].[CH2:22](O)[CH3:23]>S(=O)(=O)(O)O>[F:1][C:2]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:3]=1[O:4][C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[N+:14]([O-:16])=[O:15])[C:8]([O:10][CH2:22][CH3:23])=[O:9]

Participants

4

Reactant 2

HCID 702EthanolHCID 10402218HCID 10402218, compound

Product 1

HCID 10426327HCID 10426327, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Procedure

A mixture of 3-(2,4-difluorophenoxy)-4-nitrobenzoic acid (1.0 g) and sulfuric acid (3 drops) in ethanol (5 ml) was refluxed for 8 hours. Ethanol was evaporated under reduced pressure, and the residue was dissolved in ethyl acetate, washed with a saturated aqueous solution of sodium bicarbonate, dried over magnesium sulfate, and concentrated to give pale brown needles of ethyl 3-(2,4-difluorophenoxy)-4-nitrobenzoate (1.1 g).

Workup

  1. temperaturewas refluxed for 8 hours
  2. customEthanol was evaporated under reduced pressure
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. washwashed with a saturated aqueous solution of sodium bicarbonate
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-105ee1a6c2be4e77a071b7db2af7cbfa
Source dataset
uspto-grants-1989_09
Patent number
US04866091

Reaction notes

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