Pyridine → HCID 19850901, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4'-amino-3'-(2,4-difluorophenoxy)acetophenone (1.7 g), pyridine (0.52 g), and iodobenzene dichloride (1.8 g) in tetrahydrofuran (20 ml) was stirred overnight at 5° C. The mixture was concentrated. The residue was dissolved in ethyl acetate and washed with water, an aqueous solution of sodium bisulfite, and water. The organic layer was evaporated to give a powder of 4'-amino-3'-chloro-5'-(2,4-difluorophenoxy)acetophenone (1.5 g).

Provenance & Evidence