HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → 2'-(2,4-Difluorophenoxy)-4'-formylmethanesulfonanilide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | N-[4-cyano-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide | HCID 10358871 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | 2'-(2,4-Difluorophenoxy)-4'-formylmethanesulfonanilide | HCID 10404154 | — |
Reaction Steps
A mixture of 4'-cyano-2'-(2,4-difluorophenoxy)methanesulfonanilide (1.5 g) and Raney's Nickel (1.5 g) in 75% formic acid (40 ml) was refluxed for 2 hours. The mixture was filtered and the filtrate was concentrated to dryness. The residue was recrystallized from ethanol to give pale yellow needles of 2'-(2,4-difluorophenoxy)-4'-formylmethanesulfonanilide (1.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04866091 |
| Source dataset | uspto-grants-1989_09 |
| ORD ID | ord-3e809afbf2f64fc6873e6e5c47611791 |
| Source note | uspto-grants-1989_09 |