Acetic Anhydride → HCID 14305461, compound

Participants

Reaction Steps

A solution of 4'-(2-amino-4-thiazolyl)-2'-(2,4-difluorophenoxy)methanesulfonanilide (1.2 g) in acetic anhydride (3 ml) was stirred for 30 minutes at 80° C. The mixture was concentrated, and then evaporated with xylene and ethanol. The residue (1.4 g) was purified by column chromatography on silica gel (30 g) eluting with a mixture of toluene and ethyl acetate (1:1), and recrystallized from ethanol to afford pale brown crystals of 4'-(2-acetamido-4-thiazolyl)-2'-(2,4-difluorophenoxy)methanesulfonanilide (0.82 g).

Provenance & Evidence