Pyridine → HCID 19850891, compound

Participants

Reaction Steps

A solution of 4'-bromoacetyl-2'-(2,4-difluorophenoxy)methanesulfonanilide (2.5 g) and pyridine (526 mg) in dichloromethane (20 ml) was refluxed for 4 hours. The mixture was concentrated, and the residue was dissolved in water and washed with ethyl acetate. To the aqueous layer was added sodium bicarbonate, giving an amorphous powder. The powder 0.76 g) was dissolved in an ethanolic solution of hydrogen chloride. The residue obtained by evaporation of the solution was crystallized with ethyl acetate to give a powder of 1-[3-(2,4-difluorophenoxy)-4-(methanesulfonamido)benzoylmethyl]pyridinium chloride (0.75 g).

Provenance & Evidence