反应详情

温度

60 °C

A mixture of 3-(2,4-difluorophenoxy)-4-methanesulfonamidobenzoyl chloride (0.7 g) and potassium thiocyanate (0.73 g) in toluene (6 ml) was refluxed overnight. Ethyl mercaptan (0.68 ml) was added to the resulting mixture. The mixture was stirred for 5 hours at 60° C. and concentrated. The residue was dissolved in ethyl acetate and washed with water. The organic layer was dried and concentrated to give a yellow powder of ethyl N-[3-(2,4-difluorophenoxy)-4-methanesulfonamidobenzoyl]dithiocarbamate (0.83 g).

1. temperaturewas refluxed overnight
2. concentrationconcentrated
3. dissolutionThe residue was dissolved in ethyl acetate
4. washwashed with water
5. customThe organic layer was dried
6. concentrationconcentrated