Acetate → 3,3'-[7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethylporphyrin-2,18-diyl]dipropanoic acid

HRID 1607709Notes

Reaction equation

HRID 1607709 reaction equation
S(=O)(=O)(O)O.[CH3:6][C:7]1[C:25]2[NH:26][C:9](=[CH:10][C:11]3[C:40]([CH3:41])=[C:39]([CH2:42][CH2:43][C:44]([OH:46])=[O:45])[C:13](=[CH:14][C:15]4[C:32]([CH2:33][CH2:34][C:35]([OH:37])=[O:36])=[C:31]([CH3:38])[C:17](=[CH:18][C:19]5[NH:23][C:22]([CH:24]=2)=[C:21]([CH:27]([OH:29])[CH3:28])[C:20]=5[CH3:30])[N:16]=4)[N:12]=3)[C:8]=1[CH:47]([OH:49])[CH3:48].Cl.C([O-])(=O)C>C(O)(=O)C>[CH3:30][C:20]1[C:21]([CH:27]([OH:29])[CH3:28])=[C:22]2[NH:23][C:19]=1[CH:18]=[C:17]1[C:31]([CH3:38])=[C:32]([CH2:33][CH2:34][C:35]([OH:37])=[O:36])[C:15]([CH:14]=[C:13]3[N:12]=[C:11]([CH:10]=[C:9]4[C:8]([CH:47]([OH:49])[CH3:48])=[C:7]([CH3:6])[C:25](=[CH:24]2)[NH:26]4)[C:40]([CH3:41])=[C:39]3[CH2:42][CH2:43][C:44]([OH:46])=[O:45])=[N:16]1

Participants

5

Reactant 3

HCID 175AcetateHCID 1118Sulfuric AcidHCID 3084279Hematoporphyrin hydrochloride

Product 1

HCID 111033,3'-[7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethylporphyrin-2,18-diyl]dipropanoic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The process of claim 1 wherein hematoporphyrin derivative is prepared by adding a first mixture of acetic acid and sulfuric acid to hematoporphyrin hydrochloride, stirring for one hour to obtain a second mixture, adding the second mixture to a solution of 5% soldium acetate to obtain a red precipitate, and recovering the red precipitate.

Workup

  1. additionby adding
  2. customto obtain a second mixture
  3. additionadding the second mixture to a solution of 5%
  4. customto obtain a red precipitate
  5. customrecovering the red precipitate

Sources & evidence

ORD record
ord-707fd08ce7574c4fa850fe4e7fcea189
Source dataset
uspto-grants-1989_09
Patent number
US04866168

Reaction notes

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