Dimethylformamide → HCID 14231038, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-fluoromethyl-2-phthalimido-6-iodohexanenitrile (9.0 g, 22.5 mmol), dry DMF (30 ml), and potassium phthalimide (4.2 g, 1 equivalent) is stirred and heated at 80° C. for 4 hours. The DMF is removed under reduced pressure (0.1 mm Hg), and the residue is taken up in chloroform. The chloroform mixture is filtered and the filtrate is washed with 2N NaOH, 2N HCl, and water. Evaporation of solvent gives a residue which, when dissolved in the minimum amount of acetone, crystallizes upon addition of ether. After standing at 5° C. overnight, the colourless crystals of 2-fluoromethyl-2,6-diphthalimidohexanenitrile are collected (7.0 g), m.p. (Kofler) 136° C.

Provenance & Evidence