Hydrochloric Acid → HCID 19849382, compound

Participants

Reaction Steps

A diazonium salt solution prepared from 20.1 g of 1-(4-cyano-3-aminophenyl)-4-n-propylbicyclo[2.2.2]octane, 5.2 g of sodium nitrite and 40 ml of 20 per cent hydrochloric acid is added dropwise at 0oto a solution of 9.9 g of Cu(I) chloride in 40 ml of concentrated hydrochloric acid, the mixture is then heated on a boiling water bath until the evolution of gas is complete and is allowed to cool, giving 1-(4-cyano-3-chlorophenyl)-4-n-propylbicyclo[2.2.2]octane by extracting and working up.

Provenance & Evidence