Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | HCID 19849442 | HCID 19849442 | — |
| Solvent | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| Product | HCID 15918310 | HCID 15918310 | — |
Reaction Steps
0 85 g of 1-(4-cyano-3-nitrophenyl)-4-n-pentylbicyclo[2.2.2]octane is dissolved in 8 ml of 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidone, 2.16 g of caesium fluoride are added and the mixture is heated, with stirring, at 120° C. for 2.5 hours. Dilution with water and workingup after extraction gives 1-(4-cyano-3-fluorophenyl)-4-n-pentylbicyclo[2.2.2]octane, which is purified by chromatography and crystallization. m.p. 63°; c.p. 53.3°
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04867904 |
|---|
| Source dataset | uspto-grants-1989_09 |
|---|
| ORD ID | ord-d52b62e4c7a540efbaec91984b91d32b |
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| Source note | uspto-grants-1989_09 |
|---|
