Ammonium Acetate → HCID 23035024, compound

Participants

Reaction Steps

A 1.36 g sample of 4-(3-chloropropoxy)phenylacetone, prepared above, was dissolved in 200 mL of methanol. To this was added 7.71 g of ammonium acetate followed by 0.76 g sodium cyanoborohydride with stirring. After 5 hours, the solvent was evaporated in vacuo, the residue was dissolved in 150 mL diethylether and 200 ml of 1N hydrochloric acid solution. The aqueous phase was separated and washed with a second portion of diethylether, basified to a pH of 10-12 with 6N sodium hydroxide, and extracted with three, 100 mL portions of diethylether. The basic ether extracts were combined, dried, and evaporated to dryness in vacuo to yield1.11 g of a yellow oil.

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