Triethylamine → HCID 14536422, compound

Participants

Reaction Steps

To a chilled solution of 1,2,3,4-tetrahydro-1,9-acridinediamine (4.96 g) and triethylamine (3.6 ml) in 100 ml of tetrahydrofuran was added hexanoylchloride (3.6 ml). This was stirred for five minutes, then quenched into adilute NaOH solution. The aqueous phase was extracted with ethyl acetate (3x) and dried (MgSO4). The organics were concentrated to a semi-solid which was triturated with ethyl ether to give 3.32 g of a pale yellow powder, m.p. 205°-211° C. (dec.). This was recrystallized from methanol/water to give 2.54 g of a pale yellow powder,m.p. 214°-217° (dec.).

Provenance & Evidence