4-(4-Fluorobenzoyl)piperidine → HCID 10470715, compound

HRID 1607901Notes

Reaction equation

HRID 1607901 reaction equation
N1(C2NC=CN=2)CCCCC1.N1([C:17]2[CH:22]=[CH:21][C:20]([C:23]([CH:25]3[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[CH2:27][CH2:26]3)=[O:24])=[CH:19][CH:18]=2)C=CN=C1.[F:39]C1C=CC(C(C2CCNCC2)=O)=CC=1>>[F:39][C:17]1[CH:22]=[CH:21][C:20]([C:23]([CH:25]2[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[CH2:27][CH2:26]2)=[O:24])=[CH:19][CH:18]=1

Participants

4

Reactant 3

HCID 27244404-(4-Fluorobenzoyl)piperidineHCID 14551555HCID 14551555, compoundHCID 22918532HCID 22918532, compound

Product 1

HCID 10470715HCID 10470715, compound

Procedure

For example if the desired piperidinyl imidazole derivative of Formula I is [4-(1H-imidazol-1-yl)phenyl][1-(2-phenylethyl)-4-piperidinyl]methanone; then 4-fluorophenyl-4-piperidinyl methanone is reacted with 1-halo-2-phenylethane thereby producing the intermediate of Formula IV, 4-fluorophenyl[1-(2-phenylethyl)-4-piperidinyl]methanone.

Sources & evidence

ORD record
ord-d66a428a6acb403ca45b549c01c8a542
Source dataset
uspto-grants-1989_09
Patent number
US04868194

Reaction notes

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