5-(Trifluoromethyl)isoxazole → HCID 14280193, compound

Participants

Reaction Steps

0.92 g (0.04 mol) of sodium is dissolved in 25 ml of ethanol, 5.48 g (0.04 mol) of 5-trifluoromethylisoxazole are added at 0° C. and the mixture is stirred at room temperature for 15 minutes. 16.16 g (0.04 mol) of N-(2,6-dichloro-4-trifluoromethylphenyl)-trifluoroacetohydrazide bromide are added dropwise to this mixture, while cooling, and the mixtureis subsequently stirred at 25° C. for a further 10 hours. After the sodium bromide which has precipitated out is filtered off, the filtrate isconcentrated and the residue is separatad by column chromatography. 1.65 g (9.3% of theory) of 4-cyano-3,5-di(trifluoromethyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)-pyrazole of melting point 88° C.-92° C. are obtained.

Provenance & Evidence