Water → HCID 53847768, compound

Participants

Reaction Conditions

Reaction Steps

115.5 g of N-ethoxycarbonylethyl-N-formylglycine ethyl ester are dissolved in 150 ml of ethanol, and the solution is cooled to 0° C. To it is then added dropwise a mixture of 28.0 g of potassium hydroxide, 60 ml of water and 120 ml of ethanol. The reaction mixture is stirred for 18 h at RT, and is subsequently concentrated by evaporation under reduced pressure. After the addition of a small amount of water, the mixture is acidified with concentrated hydrochloric acid to pH 1. By extraction with chloroform, drying, and concentration of the organic phase by evaporation,there is obtained N-ethoxycarbonylethyl-N-formylglycine in the form of a yellowish oil (compound No. 1.3).

Provenance & Evidence