反应详情

17.4 g of phenylacetylenecarboxylic acid ethyl ester and 15.6 g of N-(2-cyanoethyl)-N-formylglycine are dissolved in 100 ml of acetic anhydride, and the solution is refluxed for 24 h. The mixture is concentrated by evaporation under reduced pressure; the residue is then taken up in toluene, and purified by chromatography through silica gel. The solvent is evaporated off, and from the eluate is obtained 4-ethoxycarbonyl-1-(2-cyanoethyl)-3-phenylpyrrole in the form of a yellow oil (compound No. 3.3).

1. temperaturethe solution is refluxed for 24 h
2. concentrationThe mixture is concentrated by evaporation under reduced pressure
3. custompurified by chromatography through silica gel
4. customThe solvent is evaporated off