1-Methylpyrrolidine → 7-Benzoylamino-3-(1-methyl-1-pyrrolidinio)methyl-3-cephem-4-carboxylate

Participants

Reaction Steps

To a solution of 7-benzoylamino-3-chloromethyl-3-cephem-4-carboxylic acid (14 g) in tetrahydrofuran (280 ml) was added dropwise 1-methylpyrrolidine (16.9 g) over a period of 10 minutes at 10° C. After the mixture was stirred for two hours at 25°~28° C., ethyl acetate (280 ml) was added thereto. The precipitate was collected by filtration, washed with ethyl acetate and diisopropyl ether, dried over phosphorus pentoxide to give 7-benzoylamino-3-(1-methyl-1-pyrrolidinio)methyl-3-cephem-4-carboxylate.

Provenance & Evidence