2-(Bromomethyl)tetrahydro-2H-pyran → 4'-chloro-1'-[(2-isopropyl-1,3-thiazol-4-yl)methyl]spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1H)-one

HRID 160795Notes

Reaction equation

HRID 160795 reaction equation
[Br:11][CH2:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][O:18]1.[Cl:19][c:20]1[c:21]2[c:22]([cH:23][cH:24][cH:25]1)[NH:26][C:27](=[O:40])[C:28]21[CH2:29][O:30][c:31]2[c:32]1[cH:33][c:34]1[c:35]([cH:39]2)[O:36][CH2:37][O:38]1.[Cl:1][CH2:2][c:3]1[n:4][c:5]([CH:8]([CH3:9])[CH3:10])[s:6][cH:7]1>>[CH2:2]([c:3]1[n:4][c:5]([CH:8]([CH3:9])[CH3:10])[s:6][cH:7]1)[N:26]1[c:22]2[c:21]([c:20]([Cl:19])[cH:25][cH:24][cH:23]2)[C:28]2([C:27]1=[O:40])[CH2:29][O:30][c:31]1[c:32]2[cH:33][c:34]2[c:35]([cH:39]1)[O:36][CH2:37][O:38]2

Participants

4

Reactant 3

HCID 1419172-(Bromomethyl)tetrahydro-2H-pyranHCID 27631934-(Chloromethyl)-2-isopropyl-1,3-thiazoleHCID 666728244'-chlorospiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Product 1

HCID 593521044'-chloro-1'-[(2-isopropyl-1,3-thiazol-4-yl)methyl]spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1H)-one

Sources & evidence

ORD record
ord-6462931b88ee4b6c9affc4ae153d5536
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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