Benzene → HCID 53997316, compound

Participants

Reaction Steps

To a solution of 2.2 g of potassium hydroxide in 80 ml of methanol was added 7.4 g of 12α-acetoxypregna-1,4-diene-3,20-dione, and the mixture was stirred at room temperature for 10 hours. The reaction mixturewas concentrated to about one tenth the original volume by distilling off the methanol under reduced pressure. To the concentrated reaction mixture was added 150 ml of benzene, and the solution was washed in sequence with water, diluted hydrochloric acid and water and then dried over anhydrous magnesium sulfate. Low-boiling fractions were distilled off under reduced pressure and the residue was recrystallized from ethyl acetate to give 5.4g of 12α-hydroxypregna-1,4-diene-3,20-dione (Gas chromatographic analysis revealed that purity thereof was 90%). It has the following physical properties.

Provenance & Evidence