HCID 178508811, compound → N-(2,6-diamino-4-oxo-1H-pyrimidin-5-yl)formamide

HRID 1607978Notes

Reaction equation

HRID 1607978 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([N:9]=O)=[C:4]([OH:11])[N:3]=1.NC1N=C(N)C(N)=[C:15]([OH:21])N=1>C(O)=O>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([NH:9][CH:15]=[O:21])=[C:4]([OH:11])[N:3]=1

Participants

4

Reactant 2

HCID 178508811HCID 178508811, compoundHCID 178508812HCID 178508812, compound

Product 1

HCID 178508810N-(2,6-diamino-4-oxo-1H-pyrimidin-5-yl)formamide

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The invention relates to an improved process for the catalytic hydrogenation of 2,4-diamino-6-hydroxy-5-nitrosopyrimidine (DAHNP) and the reaction of the resulting 2,4,5-triamino-6-hydroxy-pyrimidine (TAHP) with formic acid to yield 2,4-diamino-5-formylamino-6-hydroxy-pyrimidine (DAFHP).

Sources & evidence

ORD record
ord-52ef8419fc1f47ffb80a87a1407e4f86
Source dataset
uspto-grants-1989_09
Patent number
US04868302

Reaction notes

Loading…