Formaldehyde → HCID 14519538, compound

HRID 1607980Notes

Reaction equation

HRID 1607980 reaction equation
[CH2:1]([O:3][C:4](=[O:17])[CH2:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[O:16])[NH:8][N:7]=1)[CH3:2].[CH2:18]=[O:19]>C(O)C>[CH2:1]([O:3][C:4](=[O:17])[CH2:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[O:16])[N:8]([CH2:18][OH:19])[N:7]=1)[CH3:2]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 348622Ethyl 2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetate

Product 1

HCID 14519538HCID 14519538, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of ethyl-4-oxo-3-H-phthalazin-1-ylacetate (23.42 g), ethanol (200 ml) and aqueous formaldehyde (37% concentration, 100 ml) was refluxed for 40 hours. This solution was concentrated to 100 ml and was then poured onto ice water (750 ml). The precipitated solid was collected and air-dried (yield: 17.1 g; m.p. 113°-114° C.).

Workup

  1. temperaturewas refluxed for 40 hours
  2. concentrationThis solution was concentrated to 100 ml
  3. additionwas then poured onto ice water (750 ml)
  4. customThe precipitated solid was collected
  5. customair-dried (yield: 17.1 g; m.p. 113°-114° C.)

Sources & evidence

ORD record
ord-4b13820e48764a8b8a2487a362842a8e
Source dataset
uspto-grants-1989_09
Patent number
US04868301

Reaction notes

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