Phosphorus tribromide → HCID 14519541, compound

HRID 1607983Notes

Reaction equation

HRID 1607983 reaction equation
[CH3:1][O:2][C:3](=[O:18])[CH2:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](=[O:15])[N:7]([CH2:16]O)[N:6]=1.P(Br)(Br)[Br:20]>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:18])[CH2:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](=[O:15])[N:7]([CH2:16][Br:20])[N:6]=1

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 14519539HCID 14519539, compound

Product 1

HCID 14519541HCID 14519541, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of methyl-3-hydroxymethyl-4-oxo-phthalazin-1-ylacetate (0.49 g), phosphorous tribromide (0.54 g) and methylene chloride (10 ml) was stirred at room temperature for 2 hours. The solution was poured onto ice-water (5 ml) and the separated methylene chloride layer was collected, dried and evaporated to obtain a light yellow solid (yield: 0.43 g; m.p. 98°-104° C.).

Workup

  1. additionThe solution was poured onto ice-water (5 ml)
  2. customthe separated methylene chloride layer was collected
  3. customdried
  4. customevaporated
  5. customto obtain a light yellow solid (yield: 0.43 g; m.p. 98°-104° C.)

Sources & evidence

ORD record
ord-6b41a938bb4a4688b632ae0e623a1741
Source dataset
uspto-grants-1989_09
Patent number
US04868301

Reaction notes

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