HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (ethoxymethylene)malonate → Diethyl [(3-chloro-4-fluoroanilino)methylidene]propanedioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 3-Chloro-4-fluoroaniline | HCID 9708 | — |
| Product | Diethyl [(3-chloro-4-fluoroanilino)methylidene]propanedioate | HCID 533801 | — |
Reaction Steps
3-Chloro-4-fluoroaniline (I) and diethyl ethoxymethylenemalonate were heated at 120°-130° C. to give diethyl (3-chloro-4-fluorophenyl)aminomethylenepropanedioate (II). The latter was cyclized by heating it at reflux in diphenyl ether to give the quinoline III.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04868305 |
| Source dataset | uspto-grants-1989_09 |
| ORD ID | ord-b56274c66e3d428fa5071eb49519e154 |
| Source note | uspto-grants-1989_09 |