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Hydrochloric Acid → N-Cyclohexyl-3-sulfanylpropanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Carbon Disulfide | HCID 6348 | — |
| 反応物 | Sodium Sulfide | HCID 14804 | — |
| 反応物 | Acrylamide, N-cyclohexyl- | HCID 137811 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-Cyclohexyl-3-sulfanylpropanamide | HCID 14618019 | 100.3% |
反応手順
Carbon disulfide (76 g) was added to a mixture of sodium sulfide (55 g) in methanol (80 g) and water (80 g) and kept at 20° C. To this was slowly added N-cyclohexylacrylamide (100 g) maintaining the pot temperature at 20°-30° C. The resulting solution was stirred for an additional 2-3 hour and neutralized with concentrated hydrochloric acid. The organic layer was separated, washed with water and evaporated to dryness to afford 122.6 g of N-cyclohexyl-3-mercaptopropionamide (90.5% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04868310 |
| 出典データセット | uspto-grants-1989_09 |
| ORD ID | ord-8ee75b997d6f40e9a3e1de5fa2a94c51 |
| 出典メモ | uspto-grants-1989_09 |