Acetic Anhydride → HCID 19850137, compound

HRID 1608009Notes

Reaction equation

HRID 1608009 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][NH:12][C:13](=[O:18])[C:14]([F:17])([F:16])[F:15])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[C:19](OC(=O)C)(=[O:21])[CH3:20]>>[C:19]([NH:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][NH:12][C:13](=[O:18])[C:14]([F:15])([F:16])[F:17])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9])(=[O:21])[CH3:20]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 12807541N-[2-(3-Amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

Product 1

HCID 19850137HCID 19850137, compound

Procedure

N-[2-(3-Amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoro acetamide (5.24 g., 0.02 moles) in acetic anhydride (20 ml) was boiled at reflux for 2 hr. The anhydride was removed under reduced pressure and the syrupy residue added to water. The grey solid was collected and recrystallised from toluene using charcoal to give the sub-title compound as cream crystals (4.0 g) mp 105°-106°.

Workup

  1. temperatureat reflux for 2 hr
  2. customThe anhydride was removed under reduced pressure
  3. additionthe syrupy residue added to water
  4. customThe grey solid was collected
  5. customrecrystallised from toluene

Sources & evidence

ORD record
ord-360be06d8cfe4de2b00a39e2a01fb966
Source dataset
uspto-grants-1989_09
Patent number
US04868306

Reaction notes

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