Water → HCID 14014991, compound

Participants

Reaction Steps

3.89 g (10 mmol) of ethyl 7-benzenesulphonylamino-5,6,7,8-tetrahydronaphth-1-yl-oxyacetate and 840 mg (15 mmol) of KOH are stirred in 50 ml of C2H5OH and 20 ml of H2O at room temperature for 20 hours. The solvent is stripped off, the residue is partitioned between H2O and CH2Cl2, the mixture is brought to pH 4.5 with 10% strength HCl and extracted twice with CH2Cl2, the organic phases are dried over MgSO4 and concentrated in vacuo, the residue is triturated with ether and the crystals are filtered off with suction and dried.

Provenance & Evidence