Methanol → 5-Benzoylamino-5,6,7,8-tetrahydro-naphth-1-yl-oxyacetic acid

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Reaction Steps

50 mmol of methyl 5-benzoylamino-5,6,7,8-tetrahydro-naphth-1-yl-oxyacetate are stirred in 60 ml of 1N NaOH and 120 ml of MeOH at room temperature for 6 hours. The methanol is stripped off, the NaOH solution is extracted by shaking with ethyl acetate and the extract is then acidified with 10% strength HCl solution. The acid solution is extracted by shaking 3 times with ethyl acetate or tetrahydrofuran, the extract is dried over Na2SO4 and evaporated and the residue is dried under a high vacuum.

Provenance & Evidence