Sulfuric Acid → HCID 3080535, compound

HRID 1608101Notes

Reaction equation

HRID 1608101 reaction equation
[C:1]([C:3]1[C:4]([Br:16])=[C:5]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[C:6]([Br:10])=[CH:7][C:8]=1[Br:9])#[N:2].S(=O)(=O)(O)[OH:18]>>[C:1]([C:3]1[C:4]([Br:16])=[C:5]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[C:6]([Br:10])=[CH:7][C:8]=1[Br:9])(=[O:18])[NH2:2]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 19848351HCID 19848351, compound

Product 1

HCID 3080535HCID 3080535, compound

Conditions

Temperature
60 °C

Procedure

13 g of 3-(3-cyano-2,4,6-tribromophenyl)propionic acid is suspended in 50 ml of concentrated sulfuric acid and heated initially to 60° C. for 30 minutes and thereafter to 95° C. for 2 hours. The solution is then poured on 300 g of ice and agitated for 3 hours in an ice bath. The thus-precipitated product is vacuum-filtered, washed with ice water, and dried at 50° C. under vacuum. Yield: 14 g of 3-(3-carbamoyl-2,4,6-tribromophenyl)propionic acid with 90% of theory, mp 197° C.

Workup

  1. filtrationThe thus-precipitated product is vacuum-filtered
  2. washwashed with ice water
  3. customdried at 50° C. under vacuum

Sources & evidence

ORD record
ord-3fdedc9317804547a1ed7da2263d8ed8
Source dataset
uspto-grants-1989_09
Patent number
US04869913

Reaction notes

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