Sodium Hydroxide → HCID 15044919, compound

HRID 1608144Notes

Reaction equation

HRID 1608144 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH2:15])[CH3:7])C.[OH-].[Na+]>>[CH3:7][N:6]1[CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH:15][C:4](=[O:3])[CH2:5]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 19836753HCID 19836753, compound

Product 1

HCID 15044919HCID 15044919, compound

Conditions

Temperature
150 °C

Procedure

2.0 g N-(o-aminobenzyl)sarcosine ethyl ester was dissolved in 40 g polyphosphoric acid and the mixture was heated to 150° C. for two hours, then cooled and charged with 300 ml icewater.pH was adjusted to 8 with 50% NaOH and the mixture was extracted with dichloromethane. The organic phase was dried over Na2SO4 and evaporated to give the title compound.

Workup

  1. temperaturecooled
  2. additioncharged with 300 ml
  3. extractionthe mixture was extracted with dichloromethane
  4. dry with materialThe organic phase was dried over Na2SO4
  5. customevaporated

Sources & evidence

ORD record
ord-bc14c5b0503c48009e8a63ef7fe46286
Source dataset
uspto-grants-1989_09
Patent number
US04870073

Reaction notes

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